SubtiBank SubtiBank
coaA [2017-8-11 16:0:3]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

coaA [2017-8-11 16:0:3]

type I pantothenate kinase, major enzyme
locus
BSU23760
pI
5.89
mw
36.49 kDa
protein length
319 aa Sequence Blast
gene length
957 bp Sequence Blast
function
biosynthesis of coenzyme A
product
pantothenate kinase
essential
no
ec
2.7.1.33
synonyms
yqjS
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]

    • Gene

    Coordinates
    2,468,549 → 2,469,508

    The protein

    Catalyzed reaction/ biological activity

  • ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

    • Protein family

  • prokaryotic pantothenate kinase family (according to Swiss-Prot)

    • Structure

  • [PDB|1SQ5] (from ''Escherichia coli'', 49% identity, 67% similarity) [Pubmed|15136582]

    • Expression and Regulation

    Operons

    genes
    [gene|35B40D812B123766B469B8E5C0FE0EB69F671E4E|yqjP]-[gene|0927C7D45721F47F5ED2646CAAC324A308FD7724|yqjQ]-[gene|4E7390A74A8261E8B732E94859E90FE256AD64EE|dsdA]-[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]-[gene|441DCE4251C83FCBB01BC58720900365BFE7BB3D|yqjT]
    description
    [pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • MGNA-C399 (yqjS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2397 NBRP B. subtilis, Japan]

    • References

  • 1328157,24784177